John DeSantis is actor.
| Movie | Peter Pan & Wendy | Bill Jukes | 2023-04-20 |
| Series | A Series of Unfortunate Events | Bald Man | 2017-01-13 |
| Movie | Viking | Berserk | 2016-12-29 |
| Series | Supergirl | Draaga | 2015-10-26 |
| Movie | Mutant World | The Giant | 2014-09-27 |
| Movie | Seventh Son | Tusk - Zanna | 2014-12-12 |
| Series | Once Upon a Time | The Dove | 2011-10-23 |
| Series | Hell on Wheels | Irish Worker | 2011-11-06 |
| Movie | 30 Days of Night: Dark Days | Gunther | 2010-10-04 |
| Movie | Ratko: The Dictator's Son | Skender | 2009-06-01 |
| Movie | The Gambler, The Girl and The Gunslinger | Mule | 2009-07-11 |
| Movie | Stan Helsing | Frankenstein's Monster | 2009-10-23 |
| Movie | The Hole | Monster Dad | 2009-09-12 |
| Movie | The Auburn Hills Breakdown | Junior | 2008-03-01 |
| Series | Psych | L'homme grand | 2006-07-07 |
| Series | Eureka | John DeSantis | 2006-07-18 |
| Movie | Little Man | Bruno | 2006-08-31 |
| Movie | The Long Weekend | Cellmate | 2005-08-05 |
| Series | Supernatural | Moloch | 2005-09-13 |
| Movie | Bloodsuckers | Ble-Ka | 2005-07-30 |
| Series | Masters of Horror | Unknown | 2005-10-28 |
| Movie | Barbie and the Magic of Pegasus | Ollie The Giant (voice) | 2005-10-04 |
| Movie | Incident On and Off a Mountain Road | Moonface | 2005-10-28 |
| Movie | Behind the Camera: The Unauthorized Story of Charlie's Angels | Bigfoot | 2004-03-08 |
| Movie | Master and Commander: The Far Side of the World | Padeen, Loblolly Boy | 2003-11-14 |
| Movie | Snow Queen | Satan | 2002-12-07 |
| Movie | Ballistic: Ecks vs. Sever | Bus Guard #2 | 2002-09-20 |
| Series | Voyage of the Unicorn | Cratch | 2001-03-02 |
| Movie | Voyage of the Unicorn | Cratch | 2001-03-02 |
| Movie | Thir13en Ghosts | The Juggernaut | 2001-10-26 |
| Series | Smallville | The Traveler | 2001-10-16 |
| Series | Andromeda | Hsigo | 2000-10-02 |
| Series | Dark Angel | The Mangler (Miller) | 2000-10-03 |
| Movie | The 13th Warrior | Ragnar (Dour) | 1999-08-13 |
| Series | The New Addams Family | Lurch | 1998-10-19 |