Mary-Louise Parker (born August 2, 1964, height 5' 7½" (1,71 m)) is an American actress, best known for her lead role on Showtime's television series Weeds (2005–12) portraying Nancy Botwin, for which she has received several nominations and the Golden Globe Award for Best Actress in 2006. Parker has appeared in films and series such as RED, Fried Green Tomatoes, Boys on the Side, The West Wing, Angels in America, for which she received a Golden Globe and an Emmy Award for Best Supporting Actress. Parker is also the recipient of the 2001 Tony Award for Best Actress for the Broadway play Proof. Early life Parker was born in Fort Jackson, South Carolina. She is the daughter of Caroline Louise (née Morell) and John Morgan Parker, a judge who served in the U.S. Army. Her ancestry includes Swedish (from her maternal grandfather), English, Scottish, Scotch-Irish, German, and Dutch. Because of her father's career, Parker spent parts of her childhood in Tennessee and Texas, as well as in Thailand, Germany, and France. She graduated from Marcos De Niza High School in Tempe, Arizona. Parker majored in drama at the North Carolina School of the Arts.
| Movie | Face | Tanya | 2026 |
| Series | The Gray House | 2026 | |
| Movie | The Auction | 2026 | |
| Movie | El Dorado | Phillipa Rios | 2025-10-31 |
| Series | The Institute | Ms. Sigsby | 2025-07-13 |
| Movie | Woody Woodpecker Goes to Camp | Angie | 2024-04-12 |
| Movie | Omni Loop | Zoya Lowe | 2024-09-20 |
| Movie | Seneca | Agrippina | 2023-02-20 |
| Movie | Bonnie | Self | 2022-11-12 |
| Movie | The Same Storm | Roxy | 2022-10-14 |
| Movie | Adieu Aurora | Wilma Munro | 2022-09-01 |
| Series | Colin in Black and White | Teresa Kaepernick | 2021-10-29 |
| Movie | This Changes Everything | Self | 2019-06-28 |
| Movie | Golden Exits | Gwendolyn | 2018-02-09 |
| Movie | Red Sparrow | Stephanie Boucher | 2018-02-15 |
| Series | Mr. Mercedes | Janey Patterson | 2017-08-09 |
| Series | When We Rise | Roma Guy | 2017-02-27 |
| Movie | Chronically Metropolitan | Annabel | 2016-06-24 |
| Movie | Jamesy Boy | Tracy | 2014-01-03 |
| Movie | Behaving Badly | Lucy Stevens / Saint Lola | 2014-04-14 |
| Movie | Christmas in Conway | Suzy | 2013-12-01 |
| Movie | R.I.P.D. | Proctor | 2013-07-18 |
| Movie | RED 2 | Sarah Ross | 2013-07-18 |
| Movie | Warren Ellis: Captured Ghosts | Self | 2011-11-01 |
| Movie | RED | Sarah Ross | 2010-10-13 |
| Movie | Howl | Gail Potter | 2010-08-26 |
| Movie | Solitary Man | Jordon Karsch | 2009-09-07 |
| Movie | The Assassination of Jesse James: Death of an Outlaw | Self | 2008-03-31 |
| Movie | The Spiderwick Chronicles | Helen Grace | 2008-02-14 |
| Movie | The Robber Bride | Zenia Arden | 2007-03-03 |
| Movie | The Assassination of Jesse James by the Coward Robert Ford | Zee James | 2007-09-20 |
| Series | The Reichen Show | 2005-11-11 | |
| Movie | Romance & Cigarettes | Constance | 2005-09-13 |
| Movie | Vinegar Hill | Ellen Grier | 2005-03-06 |
| Series | Weeds | Nancy Botwin | 2005-08-07 |
| Movie | Saved! | Lillian | 2004-06-11 |
| Movie | The Best Thief in the World | Sue Zaidman | 2004-01-01 |
| Movie | Miracle Run | Corrine Morgan-Thomas | 2004-08-09 |
| Series | Angels in America | Harper Pitt | 2003-12-07 |
| Movie | The Quality Of Mercy | Sarah Richardson | 2002-08-01 |
| Movie | Pipe Dream | Toni Edelman | 2002-10-04 |
| Movie | Red Dragon | Molly Graham | 2002-10-02 |
| Movie | Master Spy: The Robert Hanssen Story | Bonnie Hanssen | 2002-11-10 |
| Movie | Cupid & Cate | Cate DeAngelo | 2000-05-07 |
| Movie | Let the Devil Wear Black | Julia Hirsch | 1999-01-01 |
| Movie | Goodbye Lover | Peggy Blane | 1999-04-16 |
| Movie | The Five Senses | Rona | 1999-05-18 |
| Movie | The Simple Life of Noah Dearborn | Dr. Valerie Crane | 1999-05-09 |
| Series | The West Wing | Amy Gardner | 1999-09-22 |
| Movie | Legalese | Rica Martin | 1998-10-04 |
| Movie | Saint Maybe | Lucy Dean Bedloe | 1998-11-22 |
| Movie | Murder in Mind | Caroline Walker | 1997-08-01 |
| Movie | The Maker | Officer Emily Peck | 1997-08-01 |
| Movie | The Portrait of a Lady | Henrietta Stackpole | 1996-10-17 |
| Movie | Sugartime | Phyllis McGuire | 1995-11-25 |
| Movie | Reckless | Pooty | 1995-11-17 |
| Movie | Boys on the Side | Robin | 1995-02-03 |
| Movie | Bullets Over Broadway | Ellen | 1994-10-14 |
| Movie | The Client | Dianne Sway | 1994-07-20 |
| Movie | A Place for Annie | Linda | 1994-05-01 |
| Movie | Mr. Wonderful | Rita | 1993-10-15 |
| Movie | Naked in New York | Joanne White | 1993-11-10 |
| Movie | Fried Green Tomatoes | Ruth Jamison | 1991-12-27 |
| Movie | Grand Canyon | Dee | 1991-12-25 |
| Movie | Longtime Companion | Lisa | 1989-10-11 |
| Movie | Signs of Life | Charlotte | 1989-01-01 |
| Movie | Too Young The Hero | Pearl Spencer | 1988-03-27 |
| Series | Hallmark Hall of Fame | Unknown | 1951-12-24 |