The celebration continues with the greatest hits that kicked off the new millennium from 2000-2005. The episode features an attitude-charged tribute to Destiny's Child by Fifth Harmony and epic performances by Kelsea Ballerini and Little Big Town. Music fans can also expect to see extraordinary duets by Mario & Zendaya, Lee Ann Womack & Rachel Platten and Pat Monahan & Kenny Loggins.

• Arsenio Hall
• LL Cool J
• Cee Lo Green