In the series premiere, Oprah meets the ten contestants and hands each an envelope with only the name and picture of a stranger whose lives they must change. Each contestant must use resources awarded to them to drastically improve the life of their assigned person within five days, forcing them to deal with the stress of it all by using ultimate strategy and creativity. At the end of the episode, one contestant is eliminated from the competition.

• Oprah Winfrey

• Jennifer Aniston
• John Travolta
• Jada Pinkett Smith